Table 2. Changes in vascular measurements after beer, dealcoholized beer and vodka consumption from fasting (0 h) at 1h and 2 h.
Beer | Dealc beer | Vodka | Meal effect* | Time effect** | Meal × time effect* | ||||
---|---|---|---|---|---|---|---|---|---|
Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | ||||
PWV (m/s) | |||||||||
Fasting (0 h) | 5.7 | 5.3, 6.0 | 5.8 | 5.4, 6.1 | 5.7 | 5.3, 6.1 | |||
Δ (1 h – 0 h) | -0.4 | -0.6, -0.3 | -0.2 | -0.4, -0.1 | -0.4 | -0.6, -0.2 | NS | P < 0.001*** | NS |
Δ (2 h - 0 h) | -0.5 | -0.7, -0.4 | -0.3 | -0.4, -0.1 | -0.5 | -0.7, -0.3 | |||
AIx (%)a | |||||||||
Fasting (0 h) | -2.4 | -6.8, 2.1 | -5.1 | -8.6, -1.6 | -4.8 | -9.7, 0.1 | |||
Δ (1 h – 0 h) | -9.18 | -12.3, -6.1 | -3.8 | -7.6, 0.1 | -8.4 | -11.3, -5.4 | P = 0.011 | P < 0.001 | NS |
Δ (2 h - 0 h) | -8.94 | -13.0, -4.9 | -1.7 | -4.9, 1.4 | -8.7 | -13.2, -4.3 | |||
Baseline diameter (mm)a,b | |||||||||
Fasting (0 h) | 3.9 | 3.7, 4.2 | 3.9 | 3.7, 4.2 | 3.9 | 3.6, 4.2 | |||
Δ (1 h – 0 h) | 0.3 | 0.2, 0.4 | 0.1 | -0.0, 0.1 | 0.3 | 02, 0.5 | P < 0.001 | P < 0.001 | P = 0.02 |
Δ (2 h - 0 h) | 0.3 | 0.1, 0.4 | 0.0 | -0.0, 0.1 | 0.4 | 0.3, 0.5† | |||
FMD (%)c | |||||||||
Fasting (0 h) | 2.5 | 1.4, 3.5 | 4.7 | 3.0, 6.3 | 3.9 | 2.8, 5.1 | |||
Δ (1 h – 0 h) | 1.7 | 0.3, 3.0 | -1.3 | -3.3, 0.8 | 0.1 | -1.5, 1.8 | P = 0.044 | NS | NS |
Δ (2 h - 0 h) | 1.0 | -0.4, 2.4 | -0.7 | -2.5, 1.1 | 0.2 | -0.7, 1.1 |
PWV: carotid-femoral pulse wave velocity; NS: non-significant; AIx: augmentation index; FMD: flow-mediated dilatation.
Repeated measures ANOVA of the changes at 1 h and 2 h from fasting (0 h).
Repeated measures ANOVA of the absolute values at 0 h, 1 h and 2 h (for time changes).
the time effect remained significant after adjustment for MBP
Bonferroni's correction applied when meal effect was significant:
beer v. dealc.beer, P < 0.025;
vodka v. dealc.Beer, P < 0.001;
no pairwise comparisons reached significance for FMD.
Bonferroni's correction applied when meal × time effect was significant:
v. dealc.beer, P< 0.05;
v. beer, P< 0.05.