Table 3.
Multivariable Regression Analysis of 30-Day Mortality after Lung Cancer Resection.
| Covariate | 30-day mortality | ||
|---|---|---|---|
| Odds Ratio (95% CI) | OR p Value | Type 3 p Value | |
| Clinical variables | |||
| Patient age | 1.06 (1.05-1.06) | <0.001 | <0.001 |
| Sex | <0.001 | ||
| Male | 1.55 (1.45-1.65) | <0.001 | |
| Female | - | - | |
| Charlson/Deyo Score | <0.001 | ||
| 2+ | 1.56 (1.43-1.70) | <0.001 | |
| 1 | 1.12 (1.04-1.20) | 0.002 | |
| 0 | - | - | |
| NCDB Analytic Stage Group | <0.001 | ||
| Stage IV | 1.99 (1.73-2.29) | <0.001 | |
| Stage III | 1.20 (1.10-1.32) | <0.001 | |
| Stage II | 1.14 (1.04-1.23) | 0.003 | |
| Stage 0-1 | - | - | |
| Preoperative radiation | <0.001 | ||
| Yes | 1.30 (1.12-1.52) | <0.001 | |
| No | - | - | |
| Surgical procedure | <0.001 | ||
| Pneumonectomy | 4.19 (3.62-4.84) | <0.001 | |
| Lobectomy | 1.24 (1.11-1.40) | <0.001 | |
| Segmentectomy | 1.02 (0.81-1.27) | 0.882 | |
| Wedge (< 1 lobe) | - | - | |
| Positive surgical margins | <0.001 | ||
| Yes | 1.56 (1.41-1.72) | <0.001 | |
| No | - | - | <0.001 |
| Size of tumor, cm | 1.02 (1.01-1.02) | <0.001 | |
| Histology | <0.001 | ||
| Unknown histology | 1.20 (1.04-1.38) | 0.011 | |
| Squamous cell cancer | 1.44 (1.34-1.54) | <0.001 | |
| Other histology | 0.86 (0.68-1.08) | 0.181 | |
| Large cell cancer | 1.35 (1.13-1.60) | <0.001 | |
| Adenosquamous cancer | 1.30 (1.09-1.54) | 0.004 | |
| Adenocarcinomas | - | - | |
| Non-clinical variables | |||
| Insurance coverage | 0.084 | ||
| Government insurance | 0.98 (0.89-1.08) | 0.696 | |
| Private insurance | 0.91 (0.83-1.00) | 0.05 | |
| Not insured | - | - | |
| Median local income | 0.007 | ||
| < $30,000 | 1.25 (1.10-1.42) | <0.001 | |
| $30,000 - $34,999 | 1.15 (1.03-1.28) | 0.011 | |
| $35,000 - $45,999 | 1.12 (1.02-1.23) | 0.013 | |
| > $46,000 | - | - | |
| Local education level | 0.078 | ||
| ≥29% not high school graduate | 1.16 (1.03-1.31) | 0.016 | |
| 20-28.9% not high school graduate | 1.11 (1.01-1.23) | 0.036 | |
| 14-19.9% not high school graduate | 1.05 (0.95-1.15) | 0.328 | |
| < 14% not high school graduate | - | - | |
| Facility type | <0.001 | ||
| Community | 1.34 (1.20-1.50) | <0.001 | |
| Comprehensive | 1.22 (1.14-1.31) | <0.001 | |
| Academic/Research | - | - | |
| Area of residence | 0.196 | ||
| Metropolitan | 1.07 (0.99-1.16) | 0.071 | |
| Urban | 1.03 (0.95-1.12) | 0.415 | |
| Rural | - | - | |
Variables included in the model, but not shown: grade, scope of regional lymph node surgery, number of regional lymph nodes examined, and year of diagnosis. Backward selection with an alpha level of removal of .20 was used. The following variables were removed from the model: Regional Lymph Nodes Positive, and Race: White. Number of observations in the original data set, 215,645. Number of observations used, 161,255.
OR, odds ratio.