Fig. 4.

HMP data provide parameters for modeling the distribution of within-group distances. The distribution of within-sampling-site distances is shown for 18 different human microbiome sampling sites. Four different distance metrics are depicted as applied to data from two different 16S rRNA amplicons (V1–V3 and V3–V5). The colored boxes delineate the interquartile range (IQR), and the whiskers extend to 1.5 × IQR. Outliers are depicted as points. The HMP data provide parameters according to which the within-group distance distribution can be modeled to estimate power for planned microbiome studies