Table 2.
Cdc7 IHC, clinico-pathological and molecular parameters in CRC
| Cdc7 | |||||
|---|---|---|---|---|---|
| Parameter | Negative (%) | Weak (%) | Strong (%) | p-value | |
| All cancers | 1711 | 33.6 | 57.2 | 9.2 | |
| Tumor stage | |||||
| pT1 | 75 | 25.3 | 53.3 | 21.4 | |
| pT2 | 270 | 24.1 | 64.8 | 11.1 | |
| pT3 | 1104 | 34.6 | 57.5 | 7.9 | |
| pT4 | 262 | 41.6 | 48.9 | 9.5 | <0.0001 |
| Nodal status | |||||
| pN0 | 889 | 32.2 | 58.7 | 9.1 | |
| pN1 | 458 | 36.2 | 55.0 | 8.8 | |
| pN2 | 364 | 33.8 | 56.0 | 10.2 | 0.5957 |
| Grading | |||||
| G1 | 29 | 34.5 | 37.9 | 27.6 | |
| G2 | 1505 | 32.8 | 58.3 | 8.9 | |
| G3 | 177 | 40.7 | 50.3 | 9.0 | 0.0077 |
| Tumor localization | |||||
| Right | 414 | 37.2 | 53.9 | 8.9 | |
| Transverse | 149 | 37.6 | 54.4 | 8.0 | |
| Left | 514 | 31.6 | 60.2 | 8.2 | |
| Rectum | 637 | 30.8 | 58.3 | 10.9 | 0.2093 |
| Histological type | |||||
| Tubular | 1644 | 33.5 | 57.6 | 8.9 | |
| Mucinous | 59 | 37.3 | 50.8 | 11.9 | <0.0001 |
| p53 | |||||
| Negative | 530 | 36.6 | 53.6 | 9.8 | |
| Positive | 376 | 25.3 | 63.0 | 11.7 | 0.0013 |