Table 2.
Baseline characteristics according to plaque burden measured as total percent area stenosis
| Variable (N (%)) | Q1 | Q2 | Q3 | Q4 | P value |
|---|---|---|---|---|---|
| 2.16–3.78 % | 3.86–4.95 % | 4.96–6.37 % | 6.39–13.2 % | ||
| (n = 31) | (n = 30) | (n = 31) | (n = 30) | ||
| Demographics | |||||
| Age (years), mean ± SD | 57.03 ± 14.01 | 62.47 ± 12.47 | 62.06 ± 9.71 | 63.97 ± 9.42 | 0.11 |
| Male | 17 (54.8 %) | 20 (66.7 %) | 23 (74.2 %) | 22 (73.3 %) | 0.34 |
| Black | 3 (9.7 %) | 3 (10.0 %) | 4 (12.9 %) | 1 (3.3 %) | 0.61 |
| Blood pressure (mmHg), mean ± SD | |||||
| Systolic | 123.63 ± 23.04 | 123.96 ± 25.00 | 136.52 ± 23.97 | 127.17 ± 18.05 | 0.10 |
| Diastolic | 72.03 ± 13.63 | 68.11 ± 12.87 | 71.71 ± 13.87 | 68.69 ± 12.93 | 0.57 |
| Medical history | |||||
| Acute coronary syndrome on presentation | 8 (25.8 %) | 10 (33.3 %) | 15 (48.4 %) | 10 (33.3 %) | 0.30 |
| Prior myocardial infarction | 4 (12.9 %) | 10 (33.3 %) | 8 (25.8 %) | 14 (46.7 %) | 0.03 |
| Hypertension | 20 (64.5 %) | 27 (90.0 %) | 25 (80.6 %) | 23 (76.7 %) | 0.11 |
| Diabetes | 6 (19.4 %) | 8 (26.7 %) | 16 (51.6 %) | 16 (53.3 %) | 0.01 |
| Chronic dialysis | 2 (6.5 %) | 2 (6.7 %) | 3 (9.7 %) | 1 (3.3 %) | 0.80 |
| Congestive heart failure | 7 (22.6 %) | 11 (36.7 %) | 8 (25.8 %) | 6 (20.0 %) | 0.47 |
| Chronic obstructive lung disease | 2 (6.5 %) | 3 (10.0 %) | 2 (6.5 %) | 1 (3.3 %) | 0.78 |
| Peripheral vascular disease | 0 (0.0 %) | 2 (6.7 %) | 4 (12.9 %) | 4 (13.3 %) | 0.19 |
| Hyperlipidemia | 18 (58.1 %) | 24 (80.0 %) | 26 (83.9 %) | 23 (76.7 %) | 0.09 |
| Angiographic findings | |||||
| Number of diseased vessels, median [QR] | 0.0 [0.0, 0.0] | 0.0 [0.0, 1.0] | 1.0 [1.0, 2.0] | 2.0 [2.0, 3.0] | <0.001 |
| Multi-vessel coronary disease | 0 (0.0 %) | 1 (3.3 %) | 9 (29.0 %) | 24 (80.0 %) | <0.001 |
| Gensini score, median [IQR] | 19.5 [18.5, 21.0] | 21.8 [18.5, 27.0] | 29.0 [25.5, 44.5] | 45.8 [32.5, 65.0] | <0.001 |
| Labs, mean ± SD | |||||
| Ejection fraction (%), median [IQR] | 60.00 [43.75, 63.63] | 60.00 [45.00, 65.00] | 53.00 [35.00, 65.00] | 55.00 [47.00, 60.00] | 0.46 |
| Hemoglobin, (g/dL) | 13.55 ± 1.57 | 13.30 ± 1.23 | 13.54 ± 1.66 | 12.28 ± 2.48 | 0.02 |
| White blood count (1000/mm3), median [IQR] | 7.72 [6.00, 8.55] | 7.22 [6.40, 8.60] | 7.95 [5.60, 9.34] | 8.26 [6.60, 9.14] | 0.14 |
| LDL cholesterol (mg/dL) | 101.55 ± 31.19 | 76.48 ± 30.45 | 90.04 ± 43.00 | 81.46 ± 34.67 | 0.11 |
| Serum creatinine (mg/dL), median [IQR] | 1.01 [0.81, 1.30] | 1.02 [0.90, 1.22] | 1.13 [0.90, 1.41] | 1.08 [0.85, 1.24] | 0.55 |
| Estimated glomerular filtration rate, (mL/min) | 69.01 ± 28.21 | 70.29 ± 30.70 | 64.18 ± 33.68 | 69.96 ± 29.88 | 0.85 |
Baseline characteristics of the study population according to percent area stenosis
SD standard deviation, IQR inter-quartile range, Hg mercury, min minute