Table 3.

Results of analysis of covariance (ANCOVA) of full analysis set (FAS)

Outcome	Group	Baseline	5 weeks			13 weeks
		Mean (SD)	Mean (SD)	P a	LSMD (95 % CI)a	Mean (SD)	P a	LSMD (95 % CI)a
FSS	A	4.67 (1.27)	3.39 (1.12)	<0.001	−1.14 (−1.57, −0.71)	3.32 (1.17)	<0.001	−1.01 (−1.48, −0.55)
	B	4.75 (1.07)	3.62 (1.13)	<0.001	−0.95 (−1.38, −0.52)	3.58 (1.20)	<0.001	−0.80 (−1.26, −0.34)
	C	4.48 (1.27)	4.43 (1.19)	-	-	4.24 (1.25)	-	-
SRI-short form	A	62.56 (17.95)	43.07 (15.49)	<0.001	−15.24 (−21.32, −9.16)	43.61 (15.31)	<0.001	−15.01 (−21.96, −8.06)
	B	55.67 (14.40)	42.65 (14.24)	<0.001	−11.58 (−17.45, −5.72)	40.19 (13.57)	<0.001	−14.97 (−21.67, −8.26)
	C	60.04 (18.16)	56.82 (18.10)	-	-	57.36 (20.30)	-	-
BDI	A	16.41 (8.36)	9.43 (6.98)	<0.001	−5.03 (−7.60, −2.47)	10.02 (6.40)	<0.001	−4.74 (−7.56, −1.91)
	B	15.00 (7.67)	9.04 (7.61)	<0.001	−4.63 (−7.17, −2.10)	8.20 (7.01)	<0.001	−5.88 (−8.67, −3.09)
	C	15.30 (7.05)	13.84 (6.80)	-	-	14.22 (8.32)	-	-
NRS	A	6.59 (1.44)	4.56 (2.09)	<0.001	−1.96 (−2.72, −1.20)	4.78 (2.32)	<0.001	−1.64 (−2.51, −0.78)
	B	6.55 (1.27)	4.58 (1.70)	<0.001	−1.93 (−2.68, −1.18)	4.59 (1.92)	<0.001	−1.81 (−2.67, −0.96)
	C	6.40 (1.40)	6.46 (1.39)	-	-	6.34 (1.70)	-	-
EQ-5D	A	0.84 (0.10)	0.96 (0.11)	0.025	0.04 (0.00, 0.08)	0.91 (0.11)	0.008	0.06 (0.01, 0.11)
	B	0.87 (0.09)	0.91 (0.09)	0.107	0.03 (−0.01, 0.07)	0.93 (0.09)	0.005	0.06 (0.02, 0.11)
	C	0.88 (0.11)	0.88 (0.09)	-	-	0.87 (0.15)	-	-

LSMD, least squares mean difference; CI, confidence interval; FSS, fatigue severity scale; SRI-short form, short form of the stress response inventory; BDI, Beck depression inventory; NRS, numeric rating scale; EQ-5D, EuroQol-5 dimension

^a P value with 95 % CI, Dunnett’s adjustment