Table 5.
Results of the mixed model for repeated measures (MMRM) analysis of fatigue severity scale (FSS) score in the subgroups
| Subgroup | Baseline | 5 weeks | 13 weeks | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | P a | LSMD (95 % CI)a | Interactionb | Mean (SD) | P a | LSMD (95 % CI)a | Interactionb | ||
| CFS (n = 63) | A | 5.50 (0.94) | 3.62 (1.22) | 0.993 | 0.02 (−0.51, 0.56) | 0.585c | 3.43 (1.21) | 0.924 | −0.08 (−0.64, 0.48) | 0.854c |
| B | 5.06 (0.87) | 3.75 (1.00) | 0.768 | −0.14 (−0.66, 0.38) | 3.95 (1.05) | 0.901 | −0.09 (−0.64, 0.46) | |||
| C | 4.74 (0.81) | 4.39 (0.97) | - | - | 4.44 (1.23) | - | - | |||
| ICF (n = 87) | A | 4.06 (1.14) | 3.21 (0.99) | 0.008 | −0.68 (−1.20, −0.16) | 3.27 (1.15) | 0.078 | −0.48 (−1.01, 0.04) | ||
| B | 4.50 (1.16) | 3.44 (1.21) | 0.188 | −0.37 (−0.89, 0.14) | 3.16 (1.20) | 0.235 | −0.35 (−0.87, 0.17) | |||
| C | 4.32 (1.47) | 4.51 (1.29) | - | - | 4.19 (1.25) | - | - | |||
LSMD, least squares mean difference; CI, confidence interval; CFS, chronic fatigue syndrome; ICF, idiopathic chronic fatigue
a P value with 95 % CI, Dunnett’s adjustment. bSubgroup treatment effect interaction. c P value