Table 3.
Method comparison meta-analysis summary using numerical data
| Overall group | Venous | Capillary | |
|---|---|---|---|
| n = 11,803 | n = 7,648 | n = 4155 | |
| Reference technology | |||
| Mean (absolute range) | 428 (402–453) | 436 (418–474) | 411 (384–437) |
| Median (IQR) | 383 (249–555) | 390 (254–565) | 371 (241–537) |
| Pima | |||
| Mean (absolute range) | 404 (373–425) | 416 (388–444) | 382 (351–412) |
| Median (IQR) | 363 (234–524) | 373 (242–534) | 342 (221–507) |
| Agreement | |||
| Accuracy and Precision (cells/ul) | |||
| Mean bias (Pima - Reference) | −23 | −23 | −24 |
| Mean bias (CI) | (−22;-25) | (−21; −25) | (−20; −28) |
| SD bias | 106 | 93 | 126 |
| Percentage similarity mean % | 101 | 100 | 103 |
| Percentage similarity SD % | 87 | 67 | 116 |
| Percentage similarity CV % | 86 | 67 | 113 |
| Percent bias (SD) >100 cells/μl | n = 11037, −3.26 % (26.4) | n = 7190, −3.1 % (22.5) | n = 3487, −3.54 % (32.3) |
| Concordance correlation (Pc) | 0.914 (0.911, 0.917) | 0.934 (0.931, 0.937) | 0.874 (0.867, 0.881) |
| Strength of agreement | moderate | moderate | poor |
| Overall cell variance | |||
| <100 cells/ula | 34 | 73 | |
| 100-350 cesll/ulb | 38 | 51 | |
| 350-500 cells/ulb | 33 | 57 | |
| >500 cells/ulb | 53 | 79 | |
| Percentage bias across all rangesc | 10 % | 15 % |
Calculated from abias SD; bpercentage similarity SD; cthe average percentage similarity >200cells/ul
CV coefficient of variation, IQR interquartile range, SD standard deviation