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. Author manuscript; available in PMC: 2015 Oct 13.
Published in final edited form as: Nat Commun. 2015 Apr 13;6:6768. doi: 10.1038/ncomms7768

Figure 4. Draper is required for nucleation of glial HttQ25 by neuronal HttQ91 aggregates.

Figure 4

(a) Draper is essential for transfer of HttQ91 aggregates from DA1 ORN axons to the glial cytoplasm. Maximum intensity Z-projections of the DA1 glomerulus from 7 day-old adult fly brains expressing HttQ91-mCherry in DA1 ORNs and HttQ25-YFP in glia, either without (control) or with depletion of Draper expression using two independent RNAi lines (DraperRNAi1 and DraperRNAi2) or the drprΔ5 null mutation (draper−/−). Scale bars, 5μm. (b) Quantification of the number of induced HttQ25 aggregates detected in the antennal lobe of 7 day-old adult flies as in (a) (n ≥ 8, ± s.e.m., *** p < 0.0005, one-way ANOVA followed by Tukey’s post hoc test)