Table 5.

Clinical mesenchymal stem cell-based therapies

Disease/injury	Cells	Mode of delivery	Outcome	References
Stroke	Autologous MSCs	Intravenous	Improved functional recovery	[5]
Osteogenesis imperfecta	Allogeneic MSCs	Intravenous	Increased growth velocity and no clinically significant toxicity	[48]
Radiation burns	Autologous MSCs	Injected at burn site	Promoted tissue regeneration, inhibited recurrence of inflammation	[49]
Multiple sclerosis	Autologous MSCs	Intrathecal	Some degree of improvement in sensory, pyramidal and cerebellar functions	[194]
MI	Autologous MSCs	Intracoronary	Improved left ventricular function	[146]
Crohn’s fistula	Autologous MSCs	Injected into wall of track or rectal mucosa	Six of eight fistulas were covered with epithelium; two showed incomplete closure	[195]
GVHD	Autologous and allogeneic MSCs	Intravenous	GVHD disappeared in six of eight patients	[148]
Spinal cord injury	HLA-matched MSCs	Injected into subarachnoid space	Improved sensory perception and movement in hips and thighs	[196]