Table 2.
Echocardiographic measurements in three groups of rats at week 1 and week 8
| Week 1 | Week 8 | |||||
|---|---|---|---|---|---|---|
| WKY | SHR + saline | SHR + fenofibrate | WKY | SHR + saline | SHR + fenofibrate | |
| (n= 10) | (n= 10) | (n= 14) | (n= 10) | (n= 10) | (n= 12) | |
| IVSTd (mm) | 1.34 ± 0.02 | 1.75 ± 0.06** | 1.69 ± 0.08** | 1.82 ± 0.10□□ | 2.60 ± 0.34**□□ | 2.07 ± 0.22##□□ |
| LVPWTd (mm) | 1.33 ± 0.04 | 1.66 ± 0.05** | 1.69 ± 0.07** | 1.84 ± 0.07□□ | 2.49 ± 0.24**□□ | 1.96 ± 0.15##□□ |
| LVEDD (mm) | 4.21 ± 0.30 | 4.24 ± 0.50 | 4.44 ± 0.39 | 4.76 ± 0.10□ | 4.92 ± 0.67□ | 5.04 ± 0.30□ |
| LVESD (mm) | 1.75 ± 0.11 | 1.77 ± 0.18 | 1.79 ± 0.16 | 2.01 ± 0.20□ | 2.13 ± 0.36□ | 2.04 ± 0.24□ |
| RWT | 0.63 ± 0.05 | 0.79 ± 0.09** | 0.77 ± 0.07** | 0.77 ± 0.03 | 1.04 ± 0.29*□ | 0.79 ± 0.09# |
| LVFS | 0.59 ± 0.03 | 0.58 ± 0.02 | 0.60 ± 0.05 | 0.58 ± 0.04 | 0.58 ± 0.04 | 0.59 ± 0.07 |
| LVEF | 91.15 ± 4.02 | 90.55 ± 3.11 | 89.63 ± 4.04 | 89.78 ± 3.51 | 87.69 ± 4.45 | 87.81 ± 4.15 |
| E-wave (cm/sec.) | 81.59 ± 12.87 | 80.49 ± 13.77 | 79.48 ± 18.03 | 81.81 ± 10.10 | 82.58 ± 16.84 | 83.11 ± 15.53 |
| A-wave (cm/sec.) | 45.32 ± 7.29 | 47.09 ± 9.03 | 45.75 ± 11.51 | 45.20 ± 7.26 | 61.84 ± 13.50□ | 48.34 ± 10.69 |
| E/A | 1.82 ± 0.07 | 1.72 ± 0.07 | 1.75 ± 0.11 | 1.84 ± 0.08 | 1.34 ± 0.05**□□ | 1.74 ± 0.13## |
| DT (sec.) | 37.08 ± 2.52 | 37.29 ± 1.55 | 37.87 ± 3.23 | 38.46 ± 2.49 | 43.25 ± 3.35*□□ | 38.93 ± 3.20# |
| IBS%LVPWd | 0.27 ± 0.03 | 0.30 ± 0.06 | 0.34 ± 0.07 | 0.30 ± 0.05 | 0.50 ± 0.09**□□ | 0.37 ± 0.07 ## |
| CVIBLVPWd (dB) | 7.78 ± 1.38 | 6.58 ± 1.13 | 6.35 ± 1.49 | 6.96 ± 1.49 | 4.53 ± 0.80**□□ | 6.08 ± 0.77# |
| IBS%IVS | 0.37 ± 0.04 | 0.41 ± 0.05 | 0.44 ± 0.08 | 0.42 ± 0.06 | 0.58 ± 0.12**□□ | 0.46 ± 0.09# |
| CVIBIVS (dB) | 8.38 ± 1.57 | 7.53 ± 1.43 | 6.91 ± 1.12 | 7.68 ± 1.25 | 5.22 ± 0.95**□□ | 6.83 ± 1.14# |
IVSTd: interventricular septal wall thickness
LVPWTd: left ventricular posterior wall thickness
IVSTd: interventricular septal wall thickness
LVPWTd: left ventricular posterior wall thickness
LVEDD: left ventricular end-diastolic diameter
LVESD: left ventricular end-systolic diameter
RWT: relative wall thickness
LVFS: left ventricular fractional shortening
LVEF: left ventricular ejection fraction
E/A: ratio of E wave to A wave velocities
DT: deceleration time of E wave velocities
IBS: integrated backscatter
CVIB: cyclic variation of IBS
*
P < 0.05,
**
P < 0.01 versus WKY group,
#
P < 0.05,
##
P < 0.01 versus SHR + saline group,
□
P < 0.05,
□□
P < 0.01 versus week 1 data.