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Co-crystallization of 28 with HNE. Protease residues are shown in stick representation with transparent Connolly-like surface; ligand 28 is shown in ball-and-stick representation (oxygen: red, nitrogen: blue, fluorine: cyan, sulfur: yellow). Ligand 28 has a dihedral angle of 109.5° at the northern cyanophenyl moiety along N3=C4=C1′=C2′. The image was generated with PyMOL.[29]
