Table 6.

Descriptive statistics for hormones, cytokines, & vitamin D according to baseline FRAIL scale categorization among AAH participants with no ADL disability (difficulty or dependency criterion) at baseline

	No ADL Difficulty
Baseline (N=239)	Healthy (n=136)	Prefrail (n=95)	Frail (n=8)	P-Value
sIL-6R (ng/mL)	61.55 + 24.23	59.72 + 22.12	48.63 + 11.26	.295
sIL (log10)	1.75 + 0.19	1.74 + 0.17	1.68 + 0.11	.498
sTNFR1 (ng/mL)	2.81 + 3.94	3.60 + 5.03	4.10 + 2.27	.323
sTNFR1 (log10)	0.38 + 0.18	0.46 + 0.23	0.56 + 0.22	<.001a,b
sTNFR2 (ng/mL)	7.13 + 9.51	8.76 + 14.12	6.96 + 1.93	.592
sTNFR2 (log 10)	0.78 + 0.20	0.83 + 0.24	0.82 + 0.12	.303
CRP (mg/L)	6.27 + 7.77	6.54 + 5.94	13.35 + 12.04	.026b
CRP (log10)	0.49 + 0.55	0.61 + 0.48	0.94 + 0.45	.022b,c
Adiponectin (ug/L)	8.00 + 5.39	7.85 + 5.33	6.24 + 2.45	.650
Adiponectin (log10)	0.81 + 0.29	0.82 + 0.26	0.77 + 0.17	.887
25(OH) vitamin D (ng/mL)	11.87 + 5.74	11.20 + 5.04	11.13 + 5.89	.647
25(OH) vitamin D (log10)	1.03 + 0.21	1.01 + 0.19	0.99 + 0.23	.741

	No ADL Dependence
Baseline (N=317)	Healthy (n=147)	Prefrail (n=142)	Frail (n=28)	P-Value
sIL-6R (ng/mL)	61.86 + 23.83	60.17 + 23.51	53.39 + 20.12	.215
sIL (log10)	1.76 + 0.18	1.74 + 0.18	1.70 + 0.15	.327
sTNFR1 (ng/mL)	2.78 + 3.76	3.76 + 5.58	3.47 + 1.64	.189
sTNFR1 (log10)	0.38 + 0.18	0.46 + 0.22	0.50 + 0.18	<.001a,b
sTNFR2 (ng/mL)	7.20 + 9.13	8.95 + 13.63	7.78 + 5.49	.413
sTNFR2 (log 10)	0.79 + 0.20	0.84 + 0.24	0.83 + 0.20	.151
CRP (mg/L)	5.97 + 7.45	7.13 + 6.19	9.14 + 10.17	.078
CRP (log10)	0.49 + 0.54	0.67 + 0.46	0.69 + 0.54	.005b
Adiponectin (ug/L)	8.08 + 5.32	8.32 + 5.43	7.21 + 2.79	.590
Adiponectin (log10)	0.82 + 0.29	0.84 + 0.26	0.83 + 0.17	.750
25(OH) vitamin D (ng/mL)	12.12 + 6.17	11.56 + 5.36	12.07 + 5.66	.703
25(OH) vitamin D (log10)	1.03 + 0.21	1.02 + 0.20	1.03 + 0.21	.850

^aPre-frail versus healthy p<.05 by Tukey posthoc analysis for ANOVA;

^bFrail versus healthy p<.05 by Tukey posthoc analysis for ANOVA;

^cFrail versus pre-frail p<.05 by Tukey posthoc analysis for ANOVA;