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. 2015 Jun 3;145(4):455–467. doi: 10.1111/imm.12473

Figure 2.

Figure 2

Sirt1 determined the switch of myeloid-derived suppressor cell (MDSC) differentiation into M1 or M2 MDSCs. In MDSCs, Sirt1 deficiency directs a specific switch to the M1 lineage when cells enter the periphery from bone marrow, decreasing suppressive function in favour of a pro-inflammatory M1 phenotype with more NO, tumour necrosis factor-α and IL-12. Glycolytic activation through the mammalian target of rapamycin (mTOR)-HIF1α pathway was required for differentiation to the M1 phenotype, which conferred higher tumoricidal activity.