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Proposed model for hepatitis C virus (HCV)-induced, microRNA-155 (miR-155) -modulated Tim-3 expression in regulation of interferon-γ (IFN-γ) production by natural killer (NK) cells during chronic viral infection. HCV infection inhibits nuclear factor-κB (NF-κB)-dependent miR-155 expression in NK cells, which in turn up-regulates Tim-3 expression through transcription factor T-bet. Tim-3 feedback suppresses cytokine-stimulated STAT-5 phosphorylation, so inhibiting IFN-γ production.
