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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Depress Anxiety. 2015 May 7;32(8):550–562. doi: 10.1002/da.22367

Figure 1. Schematic diagram of direct vs. indirect pathway.

Figure 1

A simplified diagram of the direct and indirect pathways through the cortex and basal ganglia are shown; thalamo-striatal projections and reciprocal connections between striatum and cortex are not shown for simplicity. Direct pathway is represented by green; indirect pathway is represented by pink. Direct pathway exerts a net excitatory effect on thalamic output to the cortex, while indirect pathway exerts a net inhibitory effect. GPi: globus pallidus interna; GPe: globus pallidus externa; STN: subthalamic nucleus; SNr: substantia nigra pars reticulata