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ENU-induced mutation in Ryr1. (A) Complementation cross of Ryr1AG/+ with Ryr1−/ + results in trans-heterozygous embryos with the same gross phenotype as Ryr1AG/AG mutants and Ryr1−/− nulls. (B, C) Immunohistochemistry of muscle fibers labeled with pan-RyR antibody. (D–G) Punctate immunostaining was observed in normal (D) and Ryr1AG/AG (E) myotubes, but not in Ryr1−/− myotubes (F). Staining was absent when only the secondary antibody was present.
