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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Jun 24;39(8):1425–1433. doi: 10.1111/acer.12774

Fig. 3.

Fig. 3

The effects of MTII alone, and in combination with the approximate ED20 (0.82 mg/kg) and ED30 (1.64 mg/kg) doses of NAL, on binge-like ethanol drinking. Neither ED20 nor ED30 doses of MTII had substantial influence on the NAL dose-effect curve. Ethanol consumption data are expressed as percent ethanol consumption (± SEM) on test day (day 4) relative to baseline ethanol consumption (averaged intake over days 1–3 of the DID procedure). Data were analyzed with a two-way, 3 × 3 (MTII dose x NAL dose) ANOVA and post hoc Tukey’s test. Post hoc comparisons of the significant MTII dose-response factor revealed that each of the MTII doses differed from each other, reflecting the dose-dependent blunting of binge-like ethanol drinking by MTII.