TABLE 3.

MULTIVARIABLE LINEAR ASSOCIATIONS BETWEEN TOTAL ADIPONECTIN AND NT-proBNP

OUTCOME: Visit 3 NT-Pro BNP (pg/ml)
Adipokine	Model 1		Model 2		Model 3*
	Estimate	p-value	Estimate	p-value	Estimate	p-value
Adiponectin (1-SD)	21.16	< 0.01	21.0	< 0.01	14.0	< 0.01
Adiponectin Quartiles
-Q2*	1.16	0.03	1.16	0.06	1.15	0.09
-Q3*	1.40	<0.01	1.41	<0.01	1.42	<0.01
-Q4*	1.74	<0.01	1.65	<0.01	1.58	<0.01
OUTCOME: NT-Pro BNP Change from Visit 1 to Visit 3 (pg/ml)
Adipokine	Model 1		Model 2		Model 3		Model 4**
	Estimate	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value
Adiponectin (1-SD)	16.9	< 0.01	16.3	< 0.01	19.8	< 0.01	23.9	< 0.01
Adiponectin Quartiles
-Q2	−7.9	0.55	−15.0	0.35	−7.7	0.65	−5.0	0.77
-Q3	13.1	0.34	14.8	0.37	13.9	0.43	18.9	0.27
-Q4	34.4	0.02	27.6	0.13	31.9	0.11	43.0	0.03

1-SD = 1-standard deviation increment of total adiponectin (13.1 μg/ml), Parameter estimate is a percent (i.e. 1.16 = 16% higher than reference)

^*R² (1-SD) = 0.36, R² (Quartiles) = 0.37;

^**R² = 0.09, R2 = 0.09

Model 1: age, sex and race

Model 2: Model 1 + height, visceral and subcutaneous fat areas, dyslipidemia, diabetes, smoking, hypertension, eGFR, leptin, aldosterone & renin

Model 3: Model 2 + left ventricular mass and left ventricular ejection fraction

Model 4: Model 3 + NT-proBNP (visit 1 value)