Skip to main content
. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Apr 22;232(16):2889–2902. doi: 10.1007/s00213-015-3925-y

Table 1.

Non-aggressive behaviors during ethanol withdrawal after memantine

Behavior Memantine
(mg/kg)		 1 week 4 weeks 8 weeks
H2O EtOH H2O EtOH H2O EtOH
Contact dH2O
3
5
10
30		 40.35 ± 11.08
45.10 ± 16.18
33.51 ± 14.40
56.74 ± 29.03		 74.70 ±21.17
65.16 ± 19.03
58.99 ± 18.98
41.51 ± 19.74		 24.42 ± 8.22
9.78 ± 4.90*
7.64 ± 254*
7.25 ± 229*		 14.67 ± 3.12
9.82 ± 215
22.59 ± 3.97#
12.83 ± 3.01		 67.04 ± 13.32
75.24 ± 24.26
57.77 ± 17.24
52.76 ± 22.63
61.50 ± 33.70		 32.51 ± 7.61
29.24 ± 8.02
32.09 ± 11.53
39.08 ± 9.98
65.80 ± 15.11
Autogroom dH2O
3
5
10
30		 260 ± 1.65
8.06 ± 3.32
4.50 ± 1.51
0.41 ± 0.21		 6.29 ± 3.18
7.64 ± 3.41
8.54 ± 3.79
6.86 ± 3.74		 3.42 ± 0.80
5.92 ± 1.62
7.36 ± 4.96
3.98 ± 1.59		 5.04 ± 0.83
3.89 ± 1.23
4.27 ± 1.09
3.59 ± 0.99		 2.02 ± 0.84
4.21 ± 2.62
5.45 ± 2.99
8.59 ± 5.79
7.10 ± 4.79		 7.60 ± 2.03
4.49 ± 1.11
4.52 ± 1.21
4.98 ± 1.58
1.49 ± 0.66*#
Rearing dH2O
3
5
10
30		 16.67 ± 5.06
24.20 ± 5.57
37.47 ± 9.41*
40.81 ± 966*		 12.65 ±3.67
20.50 ± 5.48
10.52 ± 3.98#
12.20 ± 263#		 15.23 ± 6.13
14.61 ± 3.69
12.94 ± 3.94
16.23 ± 4.24		 22.47 ± 3.83
14.55 ± 2.20
18.85 ± 3.03
776 ± 1.91		 16.35 ± 5.82
11.71 ± 3.97
13.98 ± 3.95
12.00 ± 5.88
11.58 ±7.03		 33.12 ± 5.92
38.35 ± 5.98
30.02 ± 5.08
30.72 ± 6.05
22.39 ± 4.59
Walking dH2O
3
5
10
30		 140.11 ± 12.66
10.412 ± 12.90
13.239 ± 15.96
99.14 ± 17.17		 112.97 ±16.44
10.273 ± 12.19
103.36 ± 17.60
125.99 ± 17.77		 86.68 ± 5.57
92.26 ± 7.97
76.88 ± 11.39
92.34 ± 10.16		 96.52 ± 5.90
93.76 ± 7.51
98.78 ± 5.62
89.45 ± 6.85		 116.14 ± 17.33
135.78 ± 22.99
120.17 ± 17.04
131.56 ± 15.54
79.94 ± 17.65		 159.61 ± 8.75#
177.31 ± 7.12
184.87 ± 11.54#
160.81 ± 10.51
141.76 ± 13.54#