Skip to main content
. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Feb 13;7(5):722–735. doi: 10.1002/wnan.1336

FIGURE 3.

FIGURE 3

The interior space of the P22 VLP can be utilized by introducing a scaffold via atom-transfer radical polymerization. The radical initiator 2-bromoisobutyryl aminoeythl maleimide (1) was coupled to an internal cysteine of the P22 coat protein. Polymerization of the capsid interior with 2-aminoethyl methacrylate (AEMA) introduced as many as 9000 amine sites within the intra-capsid space. These sites could then be functionalized with Gd-DPTA-NCS resulting in high particle loading. (Reprinted with permission from Ref 4. Copyright 2012 Nature Publishing Group)