TABLE 1.
The Strategies, Particle Loadings, and Effects on T1 Relaxivity (r1) of the VLP Systems Discussed in this Work are Tabulated
| VLP | Chelator | Attachment | Loading (Gd) | r1/ Gd (mM−1/second−1) |
r1/particle (mM−1/second−1) |
Ref. |
|---|---|---|---|---|---|---|
| GdCl3 | — | — | 1 | 20 | 20 | 12 |
| DTPA-Gd | DTPA | — | 1 | 4 | 4 | 4 |
| DOTA-Gd | DOTA | — | 1 | 5 | 5 | 13 |
| CCMV | Native Ca2+ site | Native | 140 | 202 | 28,280 | 12 |
| CCMV | Cal Domain | Genetic | 172 | 210 | 36,120 | 14 |
| CCMV | DOTA | NHS | 61 | 46 | 2,806 | 14 |
| MS2 | DTPA | SCN | 514 | 14 | 7,196 | 15 |
| CPMV | RNA & DOTA | RNA & Click | 268 | 15.5 | 4,154 | 16 |
| Qβ | DOTA | Click | 153 | 11.9 | 1,821 | 16 |
| TMV | DOTA | Click to interior | 3,417 | 10.7 | 36,562 | 13 |
| TMV | DOTA | Click to exterior | 1,712 | 18.4 | 31,501 | 13 |
| TMV sphere | DOTA | Click | 25,815 | 15.2 | 392,388 | 13 |
| sHSP-Branched polymer | DTPA | SCN | 159 | 19 | 3,021 | 9 |
| P22-AEMA | DTPA | SCN | 9,100 | 22 | 200,200 | 4 |
| Qβ-OEGMA | DOTA | Click | 610 | 11.6 | 7,092 | 17 |
All r1 measurements were taken between 60 and 64MHz Larmor frequency.