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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Jun 25;39(8):1312–1327. doi: 10.1111/acer.12792

Table 1.

Overview of AD genome-wide association studies (GWAS).

Reference Phenotype Study Discovery sample size GWS findings (at P<5×10−8) Replicated?
Treutlein et al., 2009 AD case-control status German GWAS 1,024 German ancestry cases, 996 German ancestry controls (male) rs7590720, rs1344694 (PECR) Not attempted
Bierut et al., 2010 AD case-control status SAGE 1,235 EA cases, 1,433 EA controls and 662 AA cases, 449 AA controls None n/a
Edenberg et al., 2010 AD case-control status COGA 847 EA cases, 552 EA controls None n/a
Kendler et al., 2011 AD criteria factor score MGS2 controls 2,357 EAs; 812 AAs None n/a
Heath et al., 2011 AD factor score OZALC 2,062 Australian cases, 3,393 Australian controls None n/a
Frank et al, 2012 AD case-control status German GWAS 1,333 German ancestry cases, 2,168 German ancestry controls (male) rs1789891 (ADH1C) Yes, in COGA
Zuo et al., 2012 AD case-control status SAGE and COGA meta-analysis 1,409 EA cases, 1,518 EA controls None n/a
Wang et al., 2013 DSM-IV AD criteria count COGA 2,322 EAs None n/a
McGue et al., 2013 AD factor score MCTFR 7,188 EAs None n/a
Park et al., 2013 AD case-control status Korean GWAS 117 Korean cases, 279 Korean controls rs1442492 and rs10516441 (ADH7), rs10516441 (ALDH2) Yes, in an independent Korean sample
Quillen et al., 2014 AD case-control status Chinese GWAS 102 Chinese cases, 212 Chinese controls (male) rs3782886 and rs671 (ALDH2) Not attempted
Gelernter et al., 2014 DSM-IV AD criteria count; AD case-control status Yale-Penn and SAGE 2,379 EAs, 3,318 AAs (Yale-Penn); 2,752 EAs, 1,311 AAs (SAGE) 14 SNPs in chromosome 4 in AAs including rs28542574 (LOC100507053) and rs2066702 (ADH1B) and rs1229984 (ADH1B) in EAs; rs1437396 on chromosome 2 (intergenic) Yes, in both an independent, identically ascertained sample and in the German GWAS sample (case-control only)

Abbreviations: AA, African-American; EA, European-American; AD, alcohol dependence; GWS, genome-wide significant