TABLE 1.
Demographic and clinical characteristics (mean (median, interquartile range)) of patients with glaucoma compared to controls.
| Controls (76 subjects) | Glaucoma (82 subjects) | P-value | |
|---|---|---|---|
| Age (years) | 61.2 ± 9.2 | 64.2 ± 12.2 | 0.093a |
| Sex, female (%) | 34 (44.7%) | 35 (42.7%) | 0.873c |
| Ethnicity | |||
| Caucasian | 53 (69.7%) | 51 (62.2%) | 0.783c |
| African-American | 17 (22.4%) | 19 (23.2%) | |
| MD worse eye (dB) | −0.2 (0.1, −0.8 to 0.7) | −6.4 (−3.9, −8.7 to −1.6) | <0.001b |
| MD better eye (dB) | 0.5 (0.7, −0.2 to 1.3) | −2.3 (−1.2, −3.4 to 0.1) | <0.001b |
| RNFL thickness worse eye (μm) | 90 (91, 83 to 98) | 71 (70, 60 to 80) | <0.001b |
| RNFL thickness better eye (μm) | 94 (94, 87 to 100) | 79 (78, 67 to 90) | <0.001b |
| Pseudophakic in at least one eye (number of patients (%)) | 10 (13.2%) | 17 (20.7%) | 0.290c |
| Montreal Cognitive Assessment score | 28 (29, 27 to 30) | 28 (28, 26 to 30) | 0.350b |
| Average distance driven per week (miles) | 143 ± 18 | 125 ± 18 | 0.065a |
| Curve Negotiation Metrics | |||
| Curve coherence | 0.93 (0.95, 0.90 to 0.97) | 0.91 (0.95, 0.89 to 0.98) | 0.978b |
| False positives (%) | 9.2 (3.1, 2.0 to 6.7) | 9.2 (2.4, 0 to 9.1) | 0.599b |
| Divided Attention Reaction Time – Low contrast (s) | 0.64 (0.59, 0.52 to 0.70) | 1.05 (0.70, 0.61 to 1.02) | <0.001b |
| Divided Attention Reaction Time – Medium contrast (s) | 0.55 (0.52, 0.48 to 0.63) | 0.59 (0.57, 0.49 to 0.64) | 0.142b |
| Divided Attention Reaction Time – High contrast (s) | 0.55 (0.53, 0.46 to 0.60) | 0.58 (0.55, 0.49 to 0.66) | 0.167b |
| Low contrast minus high contrast reaction time (s) | 0.09 (0.07, 0.03 to 0.10) | 0.47 (0.13, 0.07 to 0.40) | <0.001b |
| Car Following Metrics | |||
| Speed coherence | 0.93 (0.95, 0.90 to 0.97) | 0.91 (0.95, 0.89 to 0.98) | 0.978b |
| False positives (%) | 6.5 (2.7, 0 to 5.5) | 6.3 (2.7, 0 to 5.6) | 1.000b |
| Divided Attention Reaction Time – Low contrast (s) | 0.77 (0.62, 0.54 to 0.85) | 1.19 (0.69, 0.58 to 1.22) | 0.025b |
| Divided Attention Reaction Time – Medium contrast (s) | 0.62 (0.54, 0.50 to 0.64) | 0.62 (0.56, 0.50 to 0.66) | 0.956b |
| Divided Attention Reaction Time – High contrast (s) | 0.57 (0.54, 0.50 to 0.61) | 0.65 (0.55, 0.50 to 0.64) | 0.412b |
| Low contrast minus high contrast reaction time (s) | 0.20 (0.08, 0.03 to 0.30) | 0.48 (0.11, 0.03 to 0.60) | 0.199b |
a
t-test,
b
Wilcoxon rank sum test.
c
Fishers exact test.
Abbreviations: MD = Mean deviation, dB = decibels, RNFL = Retinal nerve fiber layer, s = seconds.