Table 2.

Gastrointestinal symptoms at baseline and after 1 year according to randomization group.

Gastrointestinal symptom rating scale, median (IQR)†	Baseline		1 year		p value‡
	Placebo	PPI∗	Placebo	PPI∗
	N = 85	N = 86	N = 69	N = 79
Total score	2.6 (2.4; 2.8)	2.5 (2.3; 2.7)	1.9 (1.7; 2.1)	1.8 (1.7; 2.0)	0.73
Abdominal pain	2.7 (2.4; 3.0)	2.6 (2.4; 2.8)	2.0 (1.8; 2.3)	1.8 (1.6; 2.0)	0.58
Reflux	3.2 (2.8; 3.5)	3.1 (2.7; 3.4)	1.8 (1.6; 2.0)	1.8 (1.6; 2.0)	0.74
Indigestion	3.1 (2.8; 3.3)	3.0 (2.7; 3.2)	2.2 (2.0; 2.5)	2.2 (1.9; 2.4)	0.83
Diarrhea	2.2 (1.9; 2.5)	1.9 (1.6; 2.1)	1.6 (1.4; 1.8)	1.5 (1.3; 1.7)	0.48
Constipation	2.2 (1.9; 2.5)	2.0 (1.7; 2.3)	1.8 (1.5; 2.0)	1.7 (1.5; 2.0)	0.88

^∗Esomeprazole 40 mg.

^†Gastrointestinal symptom rating scale. Range 1–7. Increasing values reflect increasing symptoms.

^‡Between group comparison. Difference in GSRS score at entry versus one year. Conditional linear regression adjusted for GP clusters.