Table 3.

Multivariate Analysis by Prognostic Factors (All Patients)

		Locoregional Recurrence		Distant Metastasis
		HR 95% CI	p	HR 95% CI	p
Adjuvant Radiation	No vs Yes	3.08 (0.72-13.27)	0.131	0.21 (1.31-4.22)	0.172
Tumor Size (cm)		1.57 (1.18-2.09)	0.002	2.35 (1.31-4.22)	0.004
Age at Diagnosis		1.05 (1.01-1.09)	0.027
Gender	Male vs Female	3.04 (0.80-11.60)	0.104	3.12 (0.91-10.65)	0.069
CNI	No vs Yes	0.19 (0.05-0.78)	0.021
Positive Margin	No vs Yes	0.42 (0.12-1.43)	0.165
Bone Invasion	No vs Yes	0.10 (0.01-1.04)	0.054
Primary Site	Submandibular			0.08 (0.01-0.94)	0.045
	Parotid			0.07 (0.01-0.40)	0.003
	Sublingual			Reference	-
Grade	Low/Intermediate vs High			0.19(0.04-0.94)	0.041
Degree of CNI	None			0.09(0.02-0.32)	<0.001
	Partial			0.08(0.01-0.46)	0.005
	Complete			Reference	-
T stage	T1/2 vs T3/4			6.81 (1.08-42.83)	0.041
Histology	Adenocarcinoma			7.14 (0.73-70.01)	0.092
	Acinic Cell			1.89 (0.10-36.37)	0.673
	Adenoid Cystic			9.09 (0.44-188.54)	0.154
	Mucoepidermoid			0.41 (0.01-23.90)	0.670
	Other			Reference	-

CM- centimeter, CNI-clinical nerve involvement. Bolded values denote statistical significance.