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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Endocrinol. 2015 May 1;226(2):T67–T83. doi: 10.1530/JOE-15-0121

Figure 5.

Figure 5

The trisynaptic organization of the hippocampus showing input from the entorhinal cortex to both CA3 and dentate gyrus (DG), with feed forward and feedback connections between these two regions that promotes memory formation in space and time but, at the same time, makes the CA3 vulnerable to seizure-induced excitatory (McEwen 1999). Chronic stress causes apical dendrites of CA3 neurons to debranch and shorten in a reversible manner, and glutamate release by giant mossy fiber terminals is a driving force. Chronic stress also inhibits neurogenesis in DG and can eventually reduce DG neuron number and DG volume.