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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Semin Immunol. 2015 Mar 26;27(3):177–183. doi: 10.1016/j.smim.2015.03.007

Figure 3. PMN-mediated epithelial restitution.

Figure 3

In acute mucosal inflammation, successful PMN transmigration results in transient increases in epithelial permeability. Nucleosides generated at the surface of the mucosa, such as adenosine, signal to the epithelium through adenosine receptors (e.g A2bR) to promote to the reassembly of apical junctional proteins through protein kinase A (PKA)-dependent phosphorylation of the actin-binding protein VASP. As such, this pathway represents a mechanism whereby PMN “close the door after leaving”.