Table 3.
Associations of adiponectin and Barrett’s esophagus: stratified by GERD symptom frequency3 for case vs. population controls
| Less than weekly6 | At least weekly7 | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Case | Control9 | Adjusted OR1 | 95% CI2 | Case | Control | Adjusted OR1 | 95% CI2 | |
| Total Adiponectin interaction term Quartiles4 (μg/ml8) | <0.001 | |||||||
| <7.35 | 19 | 51 | ref | 61 | 26 | ref | ||
| 7.36–10.55 | 14 | 51 | 0.67 | (0.29, 1.55) | 49 | 25 | 0.83 | (0.42, 1.64) |
| 10.56–15.41 | 9 | 60 | 0.39 | (0.16, 0.99) | 73 | 15 | 2.11 | (1.00, 4.45) |
| >15.46 | 20 | 56 | 1.24 | (0.52, 2.95) | 65 | 20 | 1.56 | (0.72, 3.37) |
| Continuous, Log-transformed | 62 | 218 | 1.16 | (0.62, 2.20) | 248 | 86 | 1.68 | (1.01, 2.80) |
|
| ||||||||
| Adiponectin High MW5 interaction term Quartiles4 (μg/ml8) | <0.001 | |||||||
| <1.46 | 20 | 48 | ref | 62 | 29 | ref | ||
| 1.46–2.53 | 14 | 53 | 0.55 | (0.24, 1.27) | 60 | 23 | 1.18 | (0.60, 2.32) |
| 2.54–4.00 | 12 | 61 | 0.42 | (0.18, 0.99) | 57 | 15 | 1.72 | (0.82, 3.63) |
| >4.02 | 16 | 56 | 0.84 | (0.35, 2.04) | 69 | 19 | 1.95 | (0.89, 4.29) |
| Continuous, Log-transformed | 62 | 218 | 0.98 | (0.64, 1.51) | 248 | 86 | 1.50 | (1.04, 2.15) |
|
| ||||||||
| Adiponectin Low + Medium MW5 interaction term Quartiles4 (μg/ml8) | <0.001 | |||||||
| <2.75 | 16 | 56 | ref | 56 | 21 | ref | ||
| 2.75–3.80 | 16 | 52 | 1.02 | (0.45, 2.33) | 62 | 24 | 0.91 | (0.45, 1.85) |
| 3.80–5.07 | 12 | 55 | 0.80 | (0.33, 1.93) | 57 | 20 | 1.16 | (0.55, 2.43) |
| >5.07 | 18 | 55 | 1.57 | (0.66, 3.72) | 73 | 21 | 1.33 | (0.62, 2.84) |
| Continuous, Log-transformed | 62 | 218 | 1.52 | (0.72, 3.21) | 248 | 86 | 1.56 | (0.87, 2.80) |
|
| ||||||||
| Adiponectin Ratio High MW5/total interaction term Quartiles4 | <0.001 | |||||||
| <0.32 | 19 | 48 | ref | 67 | 29 | ref | ||
| 0.32–0.39 | 12 | 52 | 0.56 | (0.24, 1.33) | 55 | 24 | 0.95 | (0.48, 1.86) |
| 0.39–0.47 | 16 | 60 | 0.70 | (0.31, 1.58) | 66 | 15 | 1.95 | (0.92, 4.11) |
| >0.47 | 15 | 58 | 0.73 | (0.32, 1.69) | 60 | 18 | 1.49 | (0.70, 3.17) |
| Continuous, Log-transformed | 62 | 218 | 0.66 | (0.26, 1.67) | 248 | 86 | 2.27 | (0.96, 5.41) |
1
Adjusted OR (odds ratio): adjusts for sex, age, race/ethnicity and waist circumference
2
CI: confidence interval
3
GERD: gastroesophageal reflux disease
4
Quartiles are based on population control group
5
MW= molecular weight
6
Reported frequency of GERD symptoms as less than weekly
7
Reported frequency of GERD symptoms as weekly or more than weekly
8
μg/ml= microliter per milliliter
9
Note: Not all populations controls had GERD frequency data