Table 2.
Association between overall sitting time (hrs/d) and cause-specific mortality, by sex, the NIH-AARP Diet and Health Study
| MEN | WOMEN | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |||||||
| Deaths (n) | HR | (95% CI) | HR | (95% CI) | Deaths (n) | HR | (95% CI) | HR | (95% CI) | |
| All-causes | ||||||||||
| < 5 | 1,756 | 1.00 | - | 1.00 | - | 1,081 | 1.00 | - | 1.00 | - |
| 5 to 6.9 | 2,191 | 1.05 | (0.98, 1.11) | 1.05 | (0.98, 1.11) | 1,423 | 1.11 | (1.02, 1.20) | 1.10 | (1.01, 1.19) |
| 7 to 8.9 | 1,532 | 1.11 | (1.03, 1.19) | 1.10 | (1.03, 1.18) | 1,010 | 1.11 | (1.02, 1.21) | 1.09 | (1.00, 1.19) |
| 9 to 11.9 | 896 | 1.21 | (1.11, 1.31) | 1.19 | (1.09, 1.29) | 701 | 1.29 | (1.17, 1.42) | 1.25 | (1.14, 1.38) |
| ≥ 12 | 843 | 1.23 | (1.13, 1.33) | 1.21 | (1.11, 1.31) | 768 | 1.43 | (1.30, 1.57) | 1.40 | (1.27, 1.54) |
| Ptrend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||||||
| Cardiovascular | ||||||||||
| < 5 | 457 | 1.00 | - | 1.00 | - | 269 | 1.00 | - | 1.00 | - |
| 5 to 6.9 | 623 | 1.13 | (1.00, 1.28) | 1.13 | (1.00, 1.27) | 367 | 1.12 | (0.96, 1.32) | 1.13 | (0.97, 1.33) |
| 7 to 8.9 | 430 | 1.18 | (1.03, 1.35) | 1.17 | (1.02, 1.34) | 246 | 1.06 | (0.89, 1.26) | 1.05 | (0.88, 1.25) |
| 9 to 11.9 | 267 | 1.36 | (1.16, 1.58) | 1.32 | (1.14, 1.54) | 202 | 1.44 | (1.19, 1.73) | 1.40 | (1.17, 1.69) |
| ≥ 12 | 257 | 1.42 | (1.21, 1.66) | 1.40 | (1.20, 1.63) | 221 | 1.59 | (1.33, 1.91) | 1.55 | (1.29, 1.86) |
| Ptrend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||||||
| Cancer | ||||||||||
| < 5 | 691 | 1.00 | - | 1.00 | - | 448 | 1.00 | - | 1.00 | - |
| 5 to 6.9 | 833 | 1.01 | (0.92, 1.12) | 1.01 | (0.92, 1.12) | 549 | 1.05 | (0.93, 1.19) | 1.03 | (0.91, 1.17) |
| 7 to 8.9 | 554 | 1.03 | (0.92, 1.16) | 1.03 | (0.92, 1.15) | 371 | 1.01 | (0.88, 1.17) | 1.00 | (0.87, 1.14) |
| 9 to 11.9 | 332 | 1.16 | (1.02, 1.33) | 1.15 | (1.01, 1.32) | 230 | 1.06 | (0.90, 1.25) | 1.04 | (0.88, 1.22) |
| ≥ 12 | 270 | 1.03 | (0.89, 1.19) | 1.02 | (0.88, 1.17) | 229 | 1.08 | (0.91, 1.27) | 1.06 | (0.90, 1.25) |
| Ptrend | 0.24 | 0.32 | 0.42 | 0.57 | ||||||
| Other causes | ||||||||||
| < 5 | 608 | 1.00 | - | 1.00 | - | 364 | 1.00 | - | 1.00 | - |
| 5 to 6.9 | 735 | 1.01 | (0.91, 1.13) | 1.02 | (0.92, 1.14) | 507 | 1.17 | (1.02, 1.34) | 1.16 | (1.01, 1.33) |
| 7 to 8.9 | 548 | 1.14 | (1.01, 1.28) | 1.14 | (1.01, 1.28) | 393 | 1.28 | (1.11, 1.48) | 1.25 | (1.08, 1.44) |
| 9 to 11.9 | 297 | 1.14 | (1.00, 1.32) | 1.12 | (0.97, 1.29) | 269 | 1.46 | (1.24, 1.71) | 1.41 | (1.20, 1.65) |
| ≥ 12 | 316 | 1.31 | (1.14, 1.50) | 1.27 | (1.11, 1.46) | 318 | 1.74 | (1.49, 2.03) | 1.70 | (1.45, 1.99) |
| Ptrend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||||||
Model 1: adjusted for Age (years), Education (< 12 yrs, high school graduate, some college, college graduate, unknown), Smoking history (never, stopped 10+, 5–9, 1–4 years ago, stopped < 1 year, current smoker, unknown), Sleep duration (< 4, 4, 5.9, 6, 7.9, 8, 9.9, 10+ hours/day, unknown), Overall health (excellent, very good, good, fair, poor, unknown), and Body Mass Index (< 25, 25, 29.9, 30+ kg/m2, unknown)
Model 2: additionally adjusted for Overall physical activity (< 1, 1–1.9, 2–2.9, 3–3.9, 4+ hrs/d)