Table 1.

Genotype and variant allele frequencies for polymorphisms in the Peruvian and Mexican populations.

Gene	Polymorphism	rs number	Population	n	Homozygous wild-type	Heterozygous	Homozygous variant	Variant allele frequency
ABCB1	3435C>T†	rs1045642	Peruvian	73	39	29	5	0.27
			Mexican	92	25	45	22	0.48
ABCG2	Q141K	rs2231142	Peruvian	79	49	24	6	0.23
			Mexican	93	61	27	5	0.20
CYP1B1	*3‡	rs1056836	Peruvian	70	49	19	2	0.16
			Mexican	86	50	28	8	0.26
CYP2C19	*2	rs4244285	Peruvian	80	69	10	1	0.08
			Mexican	94	75	18	1	0.11
CYP3A4	*1B	rs2740574	Peruvian	74	67	6	1	0.05
			Mexican	91	83	8	0	0.04
CYP3A5	*3C	rs776746	Peruvian	77	1	18	58	0.87
			Mexican	94	1	32	61	0.82
ERCC1	N118N	rs11615	Peruvian	78	45	30	3	0.23
			Mexican	91	46	36	9	0.30
ERCC2	K751Q	rs13181	Peruvian	78	57	20	1	0.14
			Mexican	95	68	23	4	0.16
GSTP1	I105V†	rs1695	Peruvian	65	36	23	6	0.27
			Mexican	93	23	49	21	0.49
TPMT	238G>C (*2)	rs1800462	Peruvian	80	80	0	0	0.00
			Mexican	94	94	0	0	0.00
TPMT	460G>A (*3B)‡	rs1800460	Peruvian	81	68	12	1	0.09
			Mexican	84	78	6	0	0.04
TPMT	719A>G (*3C)	rs1142345	Peruvian	76	65	10	1	0.08
			Mexican	92	84	8	0	0.04
TYMS	TSER§	rs34743033	Peruvian	73	8	34	31	0.66¶
			Mexican	91	14	34	42	0.65¶
UGT1A1	*28‡,#	rs3064744	Peruvian	78	21	37	19	0.48
			Mexican	89	35	41	11	0.36
UGT1A1	−3156G>A‡	rs10929302	Peruvian	77	21	38	18	0.48
			Mexican	94	42	40	12	0.34

^†Genotype frequencies significantly differ at p<0.001.

^‡Genotype frequencies significantly differ at p<0.05.

^§TYMS TSER*4 allele frequency = 0 in Peruvians and 0.005 in Mexicans.

^¶Frequency of TYMS TSER*3 allele.

^#(TA)₈TAA repeat allele frequency = 0.01 for both populations.