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. 2015 Jul 13;2015:159145. doi: 10.1155/2015/159145

Figure 4.

Figure 4

Intradermal EP vaccination protects BALB/c and BALB-neuT mice against a TUBO challenge. Mice were immunized twice with empty (pVAX, gray line) or ECTM (pVAX-ECTM, black line) plasmid. pVAX-ECTM treated BALB/c mice (n = 12) display total tumor protection ((a), p < 0,0001), while control group (n = 10) develops fast growing tumors within 30 days after challenge ((b), p = 0,0003). Vaccinated BALB-neuT mice (n = 7) display a delayed tumor onset ((c), p = 0,0030) and slower tumor growth (p < 0,0016) with respect to control group (n = 8). Each line refers to an individual tumor. Log-rank (Mantel-Cox) test and Student's t-test were used for statistical analysis.