. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: J Am Acad Child Adolesc Psychiatry. 2015 Jun 10;54(8):617–625. doi: 10.1016/j.jaac.2015.06.001

TABLE 3.

Research Domain Criteria Units of Analyses for Acute Threat (“Fear”)

Genes	Molecules	Cells	Circuits	Physiology	Behavior	Self-Reports	Paradigms
5-HTTLPR	NMDA Receptors	Neurons	Fear Circuit: vmPFC	Fear Potentiated	Avoidance	STAI⁹⁹	Fear Learning
GABRA2	Glutamate	Glia	Hippocampus	Startle	Freezing	SCARED¹⁰⁰	Extinction Paradigms
CRH	Glycine	Pyramidal cells	Amygdala	Heart Rate		MASC¹⁰¹	Exposure Therapy
FKBP5

Note: 5-HTTLPR = serotonin-transporter-linked polymorphic region; CRH = corticotropin releasing hormone; FKBP5 = FK506 binding protein 5; GABRA2 = gamma-aminobutyric acid receptor subunit alpha-2; MASC = Multidimensional Anxiety Scale for Children; NMDA = N-methyl-D-aspartate; SCARED = Screen for Child Anxiety Related Emotional Disorders; STAI = State-Trait Anxiety Inventory; vmPFC = ventromedial prefrontal cortex.