Table 2.

Selected clinical manifestations of sustained eosinophilia

Organ/system	Manifestations	Findings
Non-hematologic
General	fatigue
	Fever
Dermatologic	pruritus	urticaria
	angioedema	erythematous papules
Cardiac	signs/symptoms of heart failure	inflammatory/infiltrative cardiomyopathy
		endomyocardial fibrosis, including valvulopathy
	signs/symptoms of systemic embolization	mural platelet thrombi
Pulmonary	cough, rhinitis
	shortness of breath	pleural effusion
		pulmonary infiltrates
Gastrointestinal	diarrhea, with or without blood	eosinophilic colitis
	dysphagia/regurgitation	eosinophilic esophagitis/esophageal eosinophilia
	vomiting/dyspepsia/malabsorption	eosinophilic gastroenteritis
Neurologic	dysesthesia	polyneuropathy
	loss of vision	optic neuritis
Musculoskeletal	myalgias	eosinophilic myositis/fascitis
Hematologic
Peripheral blood		leukocytosis*
		eosinophilia*
		neutrophilia
		basophilia§
		left shift§
		circulating blasts§
		uni-or multilineage dysplasia§
	Pallor	anemia*
	bruisability/thrombosis	thrombocytopenia/thrombocytosis*
Reticulo-endothelial	abdominal pain	hepato-/splenomegaly§
		hepatic/splenic infarct§
	lymph node swelling	superficial and/or deep adenopathy§

^*if severe, upfront bone marrow examination should be performed;

^§Upfront bone marrow examination must be performed.