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. 2015 Jul 27;5:12453. doi: 10.1038/srep12453

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(a) The predicted miR-7a target sequence in the 3′-UTR sequence of wildtype (WT) or mutated (Mut) Myrip and Pax6 (upper panel). After co-transfected with miR-7 in 293T cells, luciferase activities of wildtype 3′-UTR in Myrip or Pax6 as well as mutated 3′-UTR in Myrip or Pax6 are measured (lower panel). (b) Effects of miR-7 and Cdr1as overexpression on endogenous mRNA levels of Myrip or Pax6 in MIN6 cells or islet cells. (c) Representative Western blots and quantitatively analysis show the effects of miR-7 and Cdr1as on the protein levels of Myrip and Pax6 in MIN6 cells. n = 3, *P < 0.05, **P < 0.01.

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