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. 2015 Jul 27;5:12453. doi: 10.1038/srep12453

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Copyright © 2015, Macmillan Publishers Limited

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Overexpression of exogenous Cdr1as or stimulation of forskolin or PMA can significantly increase the expression level of Cdr1as in islet cells, which in turn inhibits miR-7’s function in insulin biosynthesis and secretion. In particular, physiological and biological functions of two major target genes (e.g., Myrip and Pax6) of miR-7 have been well studied in islet cells. The product of the Myrip gene was found to link the Rab27A-associated and insulin-containing granules (i.e., dense-core vesicle, DCV) via Myosin 5A to the actin filaments for DCV transportation towards plasma membrane and insulin secretion. On the other hand, the transcription factor Pax6 was found to enhance insulin transcription by binding to the promoters of insulin gene 1 and 2.

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