Table 5.
Percent change from baseline and 95% confidence intervals (CI) for adjusted mean blood biomarker concentrations based on generalized estimation equation model. Means adjusted for baseline blood biomarker concentrations. All variables were analyzed in log scale and transformed prior to reporting.
| Blood Biomarker | HEPA 1st (0–21 Day) | Sham 2nd (21–42 Day) | Sham 1st (0–21 Day) | HEPA 2nd (21–42 Day) | ||||
|---|---|---|---|---|---|---|---|---|
| Adj. Mean Change | CI | Adj. Mean Change | CI | Adj. Mean Change | CI | Adj. Mean Change | CI | |
| hsCRP (mg/L) | −5% | −48%–76% | 34% | −26%–144% | −15% | −39%–19% | 6% | −10%–25% |
| Fibrinogen (mg/dL) | −2% | −12%–9% | −5% | −17%–8% | −8% | −17%–1% | −4% | −14%–7% |
| TNF-RII (pg/mL) | 2% | −5%–9% | −6% | −15%–5% | 2% | −6%–10% | −2% | −11%–7% |
| IL-6 * (pg/mL) | 24% | 9%–40% | −12% | −32%–13% | −24% | −49%–13% | 8% | −9%–28% |
Notes: Means were adjusted for baseline blood biomarker concentrations. For HEPA 1st and sham 1st, baseline = blood sample collected on day 0; for HEPA 2nd and sham 2nd, baseline = blood sample collected on day 21. All variables were analyzed on the log scale. Values in the table have been converted to normal scale by taking the exponent of the least squared mean for that variable. * Significant differences (i.e., p ≤ 0.05) between HEPA 1st and sham 1st were observed only for IL-6.