Table 2.
S1KO;S3MKO and S3MKO mice are better noncompaction cardiomyopathy (NCC) models versus other knockout mouse models.
| NCC-related Abnormalities | S1KO;S3MKO | S3MKO | RXRα KO | FKBP12 KO | |
|---|---|---|---|---|---|
| Thin ventricular wall, small septum, & disorganized trabecular network | Yes | Yes | Yes | Yes | |
|
Major Structural Defects |
Prominent myocardial trabecularization | Yes | Yes | Yes | Yes |
| Deep intertrabecular recesses | Yes | Yes | Yes | Yes | |
|
Diagnosis |
The ratio of noncompacted to compacted myocardial structure (>2) | Yes | Yes | Yes | Yes |
|
Sub-types |
Isolated form | Yes | Yes | No | No |
| Non-isolated form | Yes | Yes | Yes | Yes | |
|
Symptoms |
High mortality rate from infant to young adulthood | Yes | No | No | No |
| Left ventricular systolic dysfunction | Yes | Yes | N.A. | N.A. | |
| Blood clots in the recesses | Yes | Yes | N.A. | N.A. | |
| Myocardial infarction | Yes | Yes | N.A. | N.A. | |
N.A., not available due to lethality.