Table 2.
Associations between subunit 3 expression in different subcellular localizations in cancerous cells and clinicopathological variables of patients with hepatocellular carcinoma n (%)
| Feature | n |
CCT3 expression in cytoplasm |
P value |
CCT3 expression in nucleus |
P value | ||
| (+) | (-) | (+) | (-) | ||||
| Gender (F/M) | |||||||
| Female | 21 | 14 (18.7) | 7 (24.1) | 11 (19.0) | 10 (21.7) | ||
| Male | 83 | 61 (81.3) | 22 (75.9) | 0.533 | 47 (81.0) | 36 (78.3) | 0.726 |
| Age (yr) | |||||||
| < 60 | 56 | 39 (52.0) | 17 (58.6) | 31 (53.4) | 25 (54.3) | ||
| ≥ 60 | 48 | 36 (48.0) | 12 (41.4) | 0.544 | 27 (46.6) | 21 (45.7) | 0.927 |
| Hepatitis type | |||||||
| HBV | 85 | 59 (78.7) | 26 (89.7) | 49 (84.5) | 36 (78.3) | ||
| HCV | 6 | 4 (5.3) | 2 (6.9) | 2 (3.4) | 4 (8.7) | ||
| None | 13 | 12 (16.0) | 1 (7.7) | 0.190 | 7 (12.1) | 6 (13.0) | 0.581 |
| Cirrhosis | |||||||
| Present | 78 | 54 (72.0) | 24 (82.8) | 43 (74.1) | 35 (76.1) | ||
| None | 26 | 21 (28.0) | 5 (17.2) | 0.2561 | 5 (25.9) | 11 (23.9) | 0.820 |
| UICC stage | |||||||
| I | 64 | 46 (61.3) | 18 (62.1) | 31 (53.4) | 33 (71.7) | ||
| II | 12 | 11 (14.7) | 1 (3.4) | 0.208 | 10 (17.2) | 2 (4.3) | 0.068 |
| IIIA | 28 | 18 (24.0) | 10 (34.5) | 17 (29.3) | 11 (23.9) | ||
| Histological type | |||||||
| Well-differentiated | 26 | 16 (21.3) | 10 (34.5) | 5 (8.6) | 21 (45.7) | ||
| Moderately-differentiated | 60 | 45 (60.0) | 15 (51.7) | 36 (62.1) | 24 (52.2) | ||
| Poorly-differentiated | 18 | 14 (18.7) | 4 (13.8) | 0.371 | 17 (29.3) | 1 (2.2) | < 0.001 |
| Macrovascular invasion | |||||||
| None | 99 | 71 (94.7) | 28 (96.6) | 54 (93.1) | 45 (97.8) | ||
| Present | 5 | 4 (5.3) | 1 (3.4) | 1.000 | 4 (6.9) | 1 (2.2) | 0.380 |
| Microvascular invasion | |||||||
| None | 78 | 55 (73.3) | 23 (79.3) | 39 (67.2) | 39 (84.8) | ||
| Present | 26 | 20 (26.7) | 6 (20.7) | 0.528 | 19 (32.8) | 7 (15.2) | 0.040 |
| Tumor size (cm) | |||||||
| ≥ 5 | 46 | 35 (46.7) | 11 (37.9) | 28 (48.1) | 18 (62.9) | ||
| < 5 | 58 | 40 (53.3) | 18 (62.1) | 0.421 | 30 (51.9) | 28 (37.1) | 0.351 |
| Serum AFP level (ng/mL) | |||||||
| < 400 | 79 | 56 (74.7) | 23 (79.3) | 43 (74.1) | 36 (78.3) | ||
| ≥ 400 | 25 | 19 (25.3) | 6 (20.7) | 0. 619 | 15 (25.9) | 10 (21.7) | 0.625 |
| Tumor number | |||||||
| Solitary | 83 | 62 (82.7) | 21 (72.4) | 46 (79.3) | 37 (80.4) | ||
| Multiple | 21 | 13 (17.3) | 8 (27.6) | 0.243 | 12 (20.7) | 9 (19.6) | 0.887 |
| Liver encapsulation invasion | |||||||
| None | 93 | 66 (88.0) | 27 (93.1) | 52 (89.7) | 41 (89.1) | ||
| Present | 11 | 9 (12.0) | 2 (6.9) | 0.687 | 6 (10.3) | 5 (10.9) | 1.000 |
HBV: Hepatitis B virus; HCV: Hepatitis C virus.