. 2015 Jun 10;8(4):368–373. doi: 10.1093/ckj/sfv040

Table 1.

Mortality rates in randomized controlled trials and observational studies stratified and arranged by convection volumes, on-treatment analyses

Reference	CV# (L/treatment)^a	SV## (L/treatment)^b	IDWL (L/treatment)	HR	95% CI of HR
ESHOL^c	<23.1			0.90	0.61–1.31
2013 [9]	23.1–25.4			0.60	0.39–0.90
2013 [9]	>25.4			0.55	0.34–0.84
Turkish HDF study^d	18.8	16.2	2.6	1.10	0.68–1.76
2013 [11]	20.3	18.1	2.2	0.54	0.31–0.93
CONTRAST^c	<18.18			0.80	0.52–1.24
2012 [10]	18.18–21.95			0.84	0.54–1.29
2012 [10]	>21.95			0.61	0.38–0.98
RISCAVID^e		14		0.69
2008 [6]		23		0.46
DOPPS		5.0–14.9		0.93
2006 [5]		15.0–24.9		0.65
EUCLID 2015 [7]	22.2	19.9		0.62	0.42–0.93
Imamovic et al.^d		<20.4		0.84	0.46–1.53
2014		>20.4		0.29	0.13–0.68

^aSum of the intradialytic weight loss and the amount of substitution fluid.

^bThe amount of fluid infused into the bloodstream to compensate for water and solute movement from the blood to the dialysate.

^cIn ESHOL and CONTRAST, survival risks were reported by tertiles of convection volume (CV).

^dIn the Turkish HDF study and Imamovic et al., survival risks were reported for patients above and below the median SV (17.6 L).

^eIn RISCAVID, ‘Relative Risks’ (and not HRs) are reported for offline HDF treatment (mean SV 14 L) and online HDF (mean SV 23 L).

CI, confidence interval; CONTRAST, CONvective TRAnsport STudy; CV, convection volume (SV + net ultrafiltration); DOPPS, Dialysis Outcomes and Practice Patterns Study; ESHOL, Estudio de Supervivencia de Haemodiafiltration On-Line; HDF, Haemodiafiltration; HR, hazard ratio; IDWL, interdialytic weight loss; RISCAVID, RISchio CArdiovascolare nei pazienti afferenti all’ Area Vasta In Dialisi; EUCLID, European CLInical Database; SV, substitution volume.