Table 2.

Individual characteristics of 15 patients with proximal tubular dysfunction at the time of diagnosis of TDF-induced proximal tubulopathy

	Baselinea serum creatinine (mg/dL)	Baselinea GFR (mL/min/1.73 m2)	Months of TDF therapy	Creatinine at TDF stop (mg/dL)	GFR at TDF stop (mL/min/1.73 m2)	Change in GFR (mL/min/1.73 m2)	Serum phosphate (mg/dL)	Fractional excretion of phosphate	TmP/GFR (mg/dL)	Urine glucose	Serum potassium (meq/L)	Serum bicarbonate (meq/L)
1	0.8	97	51	1.3	58	−39	2.4	20	1.9	−	3.1	20
2	0.7	126	103	1.1	69	−57	3.6	21	2.8	+	3.8	28
3	1.0	86	54	1.3	74	−12	2.0	21	1.6	−	5.0	28
4	0.8	121	48	1.2	75	−46	2.9	24	2.2	+	4.1	23
5	1.0	83	59	1.2	64	−19	2.4	27	1.8	−	3.3	30
6	0.8	106	72	1.5	52	−54	2.0	30	1.4	−	4.2	25
7	1.0	88	70	1.5	52	−36	2.0	30	1.4	−	4.2	25
8	0.6	122	94	1.2	70	−52	3.1	30	2.2	−	4.0	26
9	0.8	103	62	1.0	77	−26	3.1	33	2.1	+	4.4	28
10	0.6	115	53	1.0	83	−32	2.2	33	1.5	+	4.3	23
11	0.5	136	56	1.1	69	−67	1.0	42	0.6	+	3.8	21
12	0.8	100	53	2.1	30	−70	2.2	44	1.1	−	3.7	21
13	0.9	111	28	1.1	85	−26	1.0	45	0.6	+	3.3	22
14	1.0	81	50	1.2	63	−18	2.6	48	1.4	−	4.5	27
15	1.0	92	103	0.5	116	24b	2.0	62	0.8	+	3.1	21

GFR, estimated glomerular filtration rate; TDF, tenofovir disoproxil fumarate; TmP, tubular maximal reabsorption of phosphate.

^aBaseline values are those recorded at the time of TDF initiation.

^bPatient had an improvement in his GFR after starting of TDF.