Figure 5.

A combination therapy of sarpogrelate and 8-OH-DPAT provide additive neuroprotection. (A) Receptor plus thicknesses and total retinal thicknesses obtained from segmented horizontal SD-OCT scans were averaged and plotted versus retinal eccentricity from the optic nerve head. The gray area indicates ±2 SD of the naïve averaged data. (B) Representative linear SD-OCT scans. (C) Electroretinogram a- and b-wave amplitudes from mice in each group were extracted from individual waveforms, averaged and plotted versus the light intensity of each flash. Averages are represented as mean ± standard error. “V” indicates at which light intensity the statistical analysis was performed. Injections followed the 5-day time course with a 1-hour light damage. Black: Naïve. Green: 8-OH-DPAT + Sarpogrelate. Blue: 1 mg/kg 8-OH-DPAT. Red: 15 mg/kg Sarpogrelate. Gray: Saline.