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Wieberdink Acute Limb Toxicity Scale
| Grade | Clinical Characteristics |
|---|---|
| I | No subjective or objective evidence of reaction |
| II | Slight erythema or edema |
| III | Considerable erythema or edema with some blistering; slightly disturbed motility permissible |
| IV | Extensive epidermolysis or obvious damage to the deep tissues causing definite functional disturbances; threatened or manifest compartmental syndromes |
| V | Reaction that may necessitate amputation |
