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. 2015 Jul 23;56(8):4725–4733. doi: 10.1167/iovs.15-16924

Figure 1.

Figure 1

Expression and activation of Csp-12 in the T17M retina during ADRP progression. We used four animals per group in this experiment and analyzed retinal protein and RNA extracts at early time points from P12 to P25. (A) Starting at P18, we observed a 6-fold (P < 0.01) increase in Csp-12 mRNA in T17M mice compared with wt. At P21 and P25, Csp-12 gene expression was upregulated between 4.5- and 1.6-fold. (B) At P21, we detected a 3-fold (P < 0.001) increase in Csp-12 activation in T17M retinas, suggesting that in addition to the UPR activation detailed in previous studies,4,6 ADRP photoreceptors also experience activation of Csp-12. One-way ANOVA was used to calculate differences. Data are shown as mean ± SEM (*P < 0.05, **P < 0.01).