CHART 1.

Effects of the main topical medications used in psoriasis during pregnancy

Medication	Adverse events in pregnancy	Adverse events in animals	Conclusion
Topical
Anthralin	No available data	No available data	Contraindicated due to the lack of available data
Calcipotriol	No available data	Increased incidence of skeletal abnormalities, and incomplete pubic bones ossification	Contraindicated due to the lack of available data
Corticoids	Intrauterine growth retardation reported	Fetal growth retardation	Safe, except when used in large amounts and extensive areas, when it can be associated with low birth weight
		Omphalocele and umbilical hernia
Coaltar	Trisomy 13, spontaneous miscarriages	Fetal death, growth retardation, cleft palate, teratogenic	Contraindicated due to the lack of available data
Salicylic acid	Oral use causes maternal and fetal hemostasis disorders	Stenosis of the ductus arterio-suswith systemic treatment	Contraindicated
	Reversible stenosis of the ductus arteriosus
	Salicylism
Tacrolimus	Low birth weight, prematurity and hyperkalemia with systemic use	Malformations, fetal growth retardation, fetal death with systemic treatment	Probably safe for topical use, however without enough data
Tazarotene	Few data in humans	Teratogenic effects and fetal death with systemic use	Contraindicated