Table 3. MicroCT bone data for Tph1 KO, Tph2 KO and Tph1/Tph2 DKO mice.
| Parameter | LV5 Tb number (1/N) | Femur length (mm) | Femur total area (mm2) |
|---|---|---|---|
| Male WT (N=10) | 4.50±0.28 | 16.5±0.1 | 2.22±0.09 |
| Male Tph1 KO (N=14) | 4.46±0.19 | 16.7±0.1 | 2.27±0.07 |
| Male Tph2 KO (N=8) | 5.62±0.43 | 16.0±0.1 | 2.23±0.07 |
| Male Tph1/Tph2 DKO (N=11) | 4.59±0.28 | 16.0±0.2 | 2.04±0.05 |
| Statistics | P=0.07 for Tph1 P=0.03 for Tph2 interaction P=0.09 | P=0.68 for Tph1 P<0.001 for Tph2 interaction P=0.44 | P=0.33 for Tph1 P=0.12 for Tph2 interaction P=0.10 |
| Female WT (N=15) | 3.10±0.13 | 16.6±0.1 | 3.10±0.13 |
| Female Tph1 KO (N=9) | 2.87±0.13 | 16.8±0.2 | 2.87±0.13 |
| Female Tph2 KO (N=14) | 3.06±0.21 | 16.6±0.1 | 3.06±0.21 |
| Female Tph1/Tph2 DKO (N=6) | 2.54±0.23 | 16.6±0.3 | 2.54±0.23 |
| Statistics | P=0.06 for Tph1 P=0.35 for Tph2 interaction P=0.46 | P=0.66 for Tph1 P=0.44 for Tph2 interaction P=0.42 | P=0.08 for Tph1 P=0.67 for Tph2 interaction P=0.52 |
Abbreviations: DKO, double knockout; KO, knockout; MicroCT, microcomputed tomography; WT, wild type.
Male and female mice were examined at 33 and 65 weeks of age, respectively.