Table 2.
Observed number of gastric cancers, crude incidence rate per 100 000 person years, and standardised incidence ratios (SIRs) with 95% confidence intervals by mucosal status at baseline*
| Mucosal status at baseline | Cardia gastric cancer | Non-cardia gastric cancer | All gastric cancer | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No of observed cases† | Crude incidence rate‡ | SIR (95% CI)§ | No of observed cases† | Crude incidence rate‡ | SIR (95% CI)§ | No of observed cases† | Crude incidence rate‡ | SIR (95% CI)§ | |||
| Correa’s cascade: | |||||||||||
| Normal | 24 | 3.9 | 1.0 (0.7 to 1.5) | 97 | 15.6 | 1.1 (0.9 to 1.3) | 121 | 19.5 | 1.0 (0.9 to 1.3) | ||
| Minor mucosal change | 5 | 5.2 | 1.0 (0.3 to 2.3) | 35 | 36.7 | 1.6 (1.1 to 2.3) | 40 | 41.9 | 1.5 (1.1 to 2.0) | ||
| Gastritis | 120 | 8.2 | 1.3 (1.1 to 1.6) | 744 | 50.8 | 1.9 (1.8 to 2.1) | 864 | 59.0 | 1.8 (1.7 to 1.9) | ||
| Atrophic gastritis | 12 | 10.3 | 1.6 (0.8 to 2.8) | 104 | 90.0 | 3.0 (2.5 to 3.7) | 116 | 100.4 | 2.8 (2.3 to 3.3) | ||
| Intestinal metaplasia | 12 | 17.6 | 2.3 (1.2 to 4.0) | 76 | 111.6 | 3.7 (2.9 to 4.6) | 88 | 129.2 | 3.4 (2.7 to 4.2) | ||
| Dysplasia | 5 | 29.9 | 3.8 (1.2 to 8.8) | 39 | 232.9 | 7.1 (5.1 to 9.8) | 44 | 262.8 | 6.5 (4.7 to 8.7) | ||
| Other diagnoses: | |||||||||||
| Cellular degeneration/infiltration or abnormal karyotype | 0 | 0 | — | 4 | 65.4 | 2.5 (0.7 to 6.3) | 4 | 65.4 | 2.0 (0.5 to 5.1) | ||
| Reactive gastropathy | 1 | 2.8 | 0.8 (0.1 to 4.3) | 3 | 8.4 | 0.7 (0.1 to 2.0) | 4 | 11.2 | 0.7 (0.2 to 1.8) | ||
| Atypia | 10 | 20.7 | 2.7 (1.3 to 4.9) | 76 | 157.5 | 4.5 (3.6 to 5.7) | 86 | 178.2 | 4.2 (3.3 to 5.2) | ||
| Hyperplasia or hypertrophy | 7 | 8.0 | 1.4 (0.6 to 2.8) | 45 | 51.2 | 2.1 (1.5 to 2.8) | 52 | 59.2 | 1.9 (1.4 to 2.5) | ||
| Metaplasia (not intestinal metaplasia) | 6 | 7.3 | 1.0 (0.4 to 2.1) | 97 | 117.7 | 3.6 (2.9 to 4.3) | 103 | 125.0 | 3.1 (2.5 to 3.7) | ||
| Polyps | 7 | 6.9 | 1.2 (0.5 to 2.5) | 52 | 51.3 | 2.1 (1.6 to 2.8) | 59 | 58.2 | 1.9 (1.5 to 2.5) | ||
| Benign tumour | 2 | 10.0 | 1.6 (0.2 to 5.9) | 16 | 80.0 | 3.0 (1.7 to 4.8) | 18 | 90.0 | 2.7 (1.6 to 4.3) | ||
*Defined as first biopsy identified in database. When multiple diagnoses were present, the most severe one was selected.
†First two years of observation and corresponding events were excluded.
‡Per 100 000 person years.
§Observed to expected number of gastric cancer cases, based on age (five year strata), sex, and calendar year (five year strata) specific incidence data in total Swedish population. 95% confidence intervals of SIRs were calculated by assuming that observed cancer occurrence followed a Poisson distribution.