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. Author manuscript; available in PMC: 2015 Jul 27.
Published in final edited form as: Int J Pharm. 2007 Dec 23;355(0):210–219. doi: 10.1016/j.ijpharm.2007.12.008

Table 4.

Effect of PKA pathway modulators on the uptake of [3H]Folic acid in Y-79 cells

Modulators (µM) Uptake (fmol/(min mg) protein)
Control 23.11 ± 3.19
IBMX
    0.1 21.44 ± 1.30
    1 18.09 ± 0.97*
    2.5 15.07 ± 2.48*
    5 10.83 ± 1.01*
IBMX (2.5 µM) + H-89 (100 µM) 25.18 ± 1.91
Forskolin
    1 24.08 ± 3.11
    10 19.71 ± 2.09
    50 13.29 ± 0.97*
    100 10.01 ± 2.17*
    Forskolin (50 µM) + H-89 (100 µM) 22.17 ± 3.15

In these studies cells were preincubated with 1 ml of PKA pathway modulators (IBMX, H-89 and Forskolin) and the uptake of [3H]Folic acid was measured. Values are means ± S.E. of five separate uptake determinations.

*

Significant difference from control (p < 0.05).