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. Author manuscript; available in PMC: 2015 Jul 27.
Published in final edited form as: J Pharm Sci. 2012 Apr 12;101(9):3249–3263. doi: 10.1002/jps.23140

Table 3.

First-Order Rate Constant (k) and Half-Life (t1/2) of Biotin-Conjugated Lipid Prodrugs in Ocular Tissue Homogenate at 37°C

Retina–Choroid
 Vitreous Humor
k (h−1) t1/2 (h) k (h−1) t1/2 (h)
B-C2-cCidofovir 2.82 ± 0.0024 24.57 ± 2.02 1.07 ± 0.0012 65.05 ± 6.87
B-C6-cCidofovir 2.71 ± 0.0026 26.09 ± 2.35 1.22 ± 0.00076 58.85 ± 3.90
B-C12-cCidofovir 3.94 ± 0.0025 17.85 ± 2.18 1.02 ± 0.00027 68.23 ± 8.10

Hydrolysis rate constant values are k× 10−2.

Each data point represents mean ± SD (n= 4).