Table 3. Factors associated with death during the intensive phase of tuberculosis treatment with all variables categorized.
| Variables | Univariate analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
| p | Odd ratios (95%CI) | p | Adjusted odd ratios (95%CI) | ||
| Sex | Male | .786 | 0.94 (0.62–1.43) | .196 | 0.67 (0.36–1.23) |
| Female | 1 | ||||
| Age, years | 20–34 | .241 | 1.01 (0.99–1.03) | .600 | 0.83 (0.40–1.69) |
| 35–49 | .763 | 1.07 (0.69–1.67) | .758 | 0.90 (0.45–1.80) | |
| 50 and more | 1 | ||||
| Level of education | Primary/No formal | .763 | 1.07 (0.69–1.67) | .997 | 1.00 (0.59–1.70) |
| Secondary/Tertiary | 1 | ||||
| Marital status | Alone (single/widowed/ divorced) | .913 | 0.97 (0.64–1.50) | .784 | 1.09 (0.58–2.06) |
| Married/Cohabitating | 1 | ||||
| Area of residence | Rural | .111 | 1.65 (0.89–3.04) | .321 | 1.50 (0.67–3.36) |
| Urban | 1 | ||||
| Year of TB diagnosis | 2006–2009 | .657 | 1.11 (0.70–1.77) | .791 | 1.09 (0.57–2.11) |
| 2010–2013 | 1 | ||||
| Clinical presentation * | SPP TB only | 1 | |||
| SNP TB only | .749 | 1.11 (0.60–2.04) | .095 | 1.97 (0.89–4.36) | |
| EP TB only | .018 | 1.84 (1.11–3.05) | .017 | 2.19 (1.51–4.17) | |
| Mixed (Pulmonary + EP TB) | .644 | 0.81 (0.33–1.97) | .875 | 1.09 (0.39–3.06) | |
| Status at TB diagnosis | New | .942 | 0.98 (0.52–1.84) | ||
| Retreatment | 1 | .336 | 1.47 (0.67–3.196) | ||
| Duration of know HIV infection, years | < 1 | 1 | |||
| ≥ 1 | .394 | 0.76 (0.40–1.43) | .186 | 0.56 (0.24–1.31) | |
| Body weight, Kg | < 50 | .939 | 1.02 (0.67–1.56) | .727 | 1.10 (0.65–1.84) |
| ≥ 50 | 1 | ||||
| Presence of another AIDS opportunistic infection | Yes | .196 | 0.73 (0.45–1.18) | .304 | 1.37 (0.75–2.47) |
| No | 1 | ||||
| Presence of non-AIDS comorbidity | Yes | .027 | 1.85 (1.07–3.20) | ||
| No | 1 | .023 | 2.23 (1.12–4.46) | ||
| Cotrimoxazole prophylactic therapy | Yes | 1 | |||
| No | .363 | 0.81 (0.52–1.27) | .769 | 1.09 (0.62–1.92) | |
| Antiretroviral therapy | Yes | 1 | |||
| No | .899 | 1.03 (0.67–1.58) | .125 | 0.65 (0.38–1.13) | |
| White blood cell count, cells/mm 3 | < 4.000 | .530 | 0.86 (0.54–1.37) | .712 | 0.90 (0.52–1.56) |
| > 10.000 | .672 | 1.14 (0.62–2.11) | .982 | 0.99 (0.47–2.09) | |
| 4.000–10.000 | 1 | ||||
| Hemoglobin level, g/dl | < 8 | .800 | 1.06 (0.69–1.62) | .565 | 0.86 (0.51–1.45) |
| ≥ 8 | 1 | ||||
| CD4 lymphocytes count, cells/mm 3 | < 50 | .434 | 0.72 (0.31–1.64) | .552 | 0.74 (0.27–2.03) |
| 50–199 | .477 | 0.73 (0.31–1.74) | .346 | 0.60 (0.21–1.74) | |
| ≥ 200 | 1 | ||||
* SPP: smear positive pulmonary, SNP: smear negative pulmonary, EP: extra-pulmonary
TB: tuberculosis